Long-term cognitive impairment without diffuse axonal injury following repetitive mild traumatic brain injury in rats
نویسندگان
چکیده
منابع مشابه
Sex matters: repetitive mild traumatic brain injury in adolescent rats
OBJECTIVE Whether sex differences contribute to the heterogeneity of mild traumatic brain injury (mTBI) and repeated mTBI (RmTBI) outcomes in adolescents is unknown. Therefore, this study examined changes in, and differences between, male and female rats following single mTBI and RmTBI. METHODS Rats were given a single mTBI, RmTBI (i.e., 3x), or sham injuries. Injuries were administered using...
متن کاملTraumatic Brain Injury at Multiple Length Scales: Relating Diffuse Axonal Injury to Discrete Axonal Impairment
The length scales involved in the development of diffuse axonal injury, typically range from the head level (i.e., mechanical loading) to the cellular level, where discrete axonal injuries are located near inclusions. The aim is to investigate the local axonal strains near an inclusion in relation to the tissue level strains of the brain stem during mechanical loading of the head and the result...
متن کاملLong-Term Kinetics of Immunologic Components and Neurological Deficits in Rats Following Repetitive Mild Traumatic Brain Injury
BACKGROUND Despite growing awareness of repetitive mild traumatic brain injury (rmTBI), understanding of the involvement of long-term kinetics of immunologic components in the central and peripheral immune system took part remains incomplete. The present study aimed to provide a quantitative assay for certain immune system parameters in rmTBI rats. MATERIAL AND METHODS Neurological functions we...
متن کاملLong-term survival following traumatic brain injury.
PURPOSE The study used a retrospective cohort design to establish long-term mortality rates and predictors of mortality for persons after moderate to severe traumatic brain injury (TBI). METHOD Consecutive records of persons with moderate to severe TBI who were discharged from a large rehabilitation hospital in Pittsburgh, Pennsylvania in the years 1974-1984, 1988 and 1989 were reviewed. RE...
متن کاملDiffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study.
OBJECT Diffuse axonal injury (DAI) is a major complication of traumatic brain injury (TBI) that leads to functional and psychological deficits. Although DAI is frequently underdiagnosed by conventional imaging modalities, it can be demonstrated using diffusion tensor imaging. The aim of this study was to assess the presence and extent of DAI in patients with mild TBI. METHODS Forty-six patien...
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ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 2020
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2019.112268